Technology

Our simulation technology is unique and as close as possible to real processes taking place in the human organism. It is built in accordance with the ’from bottom to top‘principle: cells – organs – systems – organism. In its basis lies construction of organs and maintenance of their systems, such as hemodynamic, metabolism, breathing, feeding, excretion, etc. Organs are built from working cells and stroma (skeleton). Working cells are filled with cytoplasm, where biochemical transformations occur with substances coming from the blood, as food matters enter the blood flow from the gastrointestinal tract, etc. All processes are described by well-known laws, easy for perception and interpretation.

The kernel of the simulator uses large data volume. For example, 541 metabolites and 424 ferments are used to represent each organ. In each organ, processes in arteries, arterioles, capillaries, veins and venules are simulated. In each vessel, 292 metabolites and 7 types of gases are used to simulate the passage of the blood. The simulator models 8 types of cells, containing 146 metabolites each. In total, nearly 132880 biochemical parameters, excluding physical factors like pressure in the vessels, heat transmission, etc., are involved to describe 16 organs.

Puremedsim’s technology serves as a background for various high technical education systems in theoretical and practical medicine, high quality training systems and many other systems. Medical simulators based on this technology differ significantly from other simulators and can be used in education, clinical practice and research. With the help of these simulators, doctors will be able to accurately predict the treatment outcome for a concrete patient and introduce some changes by choosing appropriate treatment. This opens virtually unlimited prospects for application of similar systems.

There is also a possibility to create separate functional systems, based on this technology (for example, “Pharmakin” – the system for researching and predicting pharmacokinetic processes; “Diabetes” – the system for solving clinical tasks of diabetes compensation). Moreover, we are able to integrate our modules with existing mannequin-type simulators…